Table III. Comparative evolution of β-defensin, veficolins and cysteine-rich secretory proteins.

		SLACa	FELb	RELc	Integrative	MEME Sitesd	PAMLg
					SLAC + FEL + REL + MEME		M8	M2a	Clade Model C (ω)h
Iguania, Varanidae and Crotalinae β-Defensin
	ω>1e	0	1	0	1		1
Iguania	ω<1f	3	9	9	14	0	(0 + 1)	0	3.61sig
	ω =	0.43	–	0.59	–		0.70	0.77
	ω>1e	0	0	12	13		14	12
Crotalinae	ω<1f	1	0	0	1	2	(6 + 8)	(6 + 6)	4.43sig
	ω =	1.42	–	4.03	–		3.23	3.22
	ω>1e	0	0	0	1
Varanidae	ω<1f	0	5	14	14	1	0	0	1.97sig
	ω =	1.10	–	–	–		1.31	1.31
Iguania and Homalopsidae Veficolins
	ω>1e	0	1	10	17		1	1
Iguania	ω<1f	11	35	80	85	8	(1 + 0)	(0 + 1)	0.33sig
	ω =	0.52	–	–	–		0.49	0.49
	ω>1e	0	0	0	3		24	14
Homalopsidae	ω<1f	2	5	34	34	3	(8 + 16)	(2 + 12)	3.06sig
	ω =	0.86	–	–	–		1.12	1.12
Anguimorpha and Caenophidia CRiSPs
	ω>1e	1	3	16	28		4	4
Anguimorpha	ω<1f	21	38	100	102	10	(2 + 2)	(2 + 2)	2.04sig
	ω =	0.56	–	0.77	–		0.70	0.83
	ω>1e	3	13	62	67		17	26
Caenophidia	ω<1f	7	19	50	59	24	(8 + 9)	(17 + 9)	3.94sig
	ω =	1.15	–	4.13	–		1.21	1.21

^a Single Likelihood Ancestor Counting.

^b Fixed-effects likelihood.

^c Random-effects likelihood.

^d Sites detected as experiencing episodic diversifying selection (0.05 significance) by the Mixed Effects Model Evolution (MEME).

^e Number of positively selected sites at 0.05 significance (for SLAC, FEL) or 50 Bayes factor (for REL).

^f Number of negatively selected sites at 0.05 significance (for SLAC, FEL) or 50 Bayes factor (for REL).

^g Positively selected sites detected using the Bayes Empirical Bayes approach implemented in the site models (M8 and M2a). Sites detected at 0.99 and 0.95 significance are indicated in the parenthesis.

^h Mean dN/dS computed by the Clade Model C analysis for Iguania versus Crotalinae crotamines and Iguania versus Colubridae veficolins; ω: mean dN/dS; sig: Clade Model C analysis significant at 0.001.