Table 1.
Variable | ASC (n = 35) | Controls (n = 20) | Siblings (n = 12) | ASC versus siblings | ASC versus controls | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | Range | Mean | SD | Range | Mean | SD | Range | |||||
Age (n = 67) | 14.48 | 1.75 | 12.01 to 18.53 | 15.27 | 1.62 | 12.29 to 17.62 | 15.30 | 2.01 | 12.10 to 18.95 | ||||
IQ (n = 67) | 108.40 | 16.15 | 81 to 146 | 114.05 | 11.39 | 83 to 131 | 114.67 | 10.78 | 97 to 129 | ||||
Asymmetry indices (AI) (n = 67) | F | p | F | p | |||||||||
Splenium AI | 0.42 | 1.55 | −2.43 to 3.46 | 0.60 | 1.61 | −2.88 to 4.27 | 0.45 | 1.61 | −2.20 to 2.73 | 1.671 | 0.203 | 0.209 | 0.65 |
Isthmus AI | −0.93 | 4.27 | −10.00 to 8.65 | 0.88 | 3.96 | −7.54 to 10.37 | 0.78 | 3.09 | −4.17 to 7.88 | 0.046 | 0.832 | 0.509 | 0.479 |
Posterior midbody AI | 0.08 | 3.45 | −12.38 to 7.38 | −1.01 | 3.94 | −9.17 to 8.96 | −1.25 | 2.81 | −5.04 to 3.79 | 0.576 | 0.452 | 14.342 | 0.000 |
Anterior midbody AI | 1.01 | 2.70 | −6.71 to 4.27 | −1.09 | 3.09 | −8.09 to 6.40 | −1.25 | 2.87 | −7.54 to 3.58 | 0.000 | 0.983 | 5.341 | 0.025 |
Rostral body AI | 0.71 | 3.40 | −7.28 to 7.90 | 0.85 | 3.77 | −5.24 to 7.15 | 0.18 | 3.95 | −7.23 to 4.29 | 0.441 | 0.511 | 0.864 | 0.357 |
Genu AI | 0.87 | 3.62 | −6.55 to 8.21 | 0.16 | 3.43 | −9.33 to 7.22 | 0.65 | 3.80 | −5.30 to 6.76 | 2.822 | 0.101 | 0.015 | 0.903 |
Rostrum AI | 7.85 | 13.24 | −40.9 to 21.4 | −5.20 | 8.69 | −21.69 to 12.37 | −6.68 | 2.00 | −35.11 to 15.88 | 0.000 | 0.997 | 0.17 | 0.898 |
Total volume AI | 0.04 | 1.50 | −4.30 to 3.45 | −0.12 | 1.60 | −3.49 to 3.14 | −0.15 | 1.24 | −2.49 to 2.36 | 0.86 | 0.36 | 2.54 | 0.118 |
Handedness (n = 62) | 51.16 | 59.81 | −89.5 to 100 | 69.19 | 44.56 | −70 to 100 | 86.20 | 14.37 | 57.89 to 100 | 105.5 | 0.082 | 259 | 0.292 |
Handedness was assessed using the Edinburgh Handedness Inventory. Values range from +100 (strongest right-handedness) to -100 (strongest left-handedness). Corpus callosum asymmetry index values > 0 indicate rightward asymmetry and values < 0 indicate leftward asymmetry. Differences in sample size are due to fewer available measures on handedness in the three groups with n = 33 for ASC, n = 19 controls and n = 10 for siblings