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. 2013 Feb 26;15(4):431–440. doi: 10.1007/s11307-013-0619-x

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© The Author(s) 2013

Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 7 — Induction of cyclin B-Luc in subcutaneous tumors treated with KSPi correlates with phospho-histone H3. Nude mice implanted with subcutaneous HCT116-cyclin B-Luc tumor xenografts were either vehicle-treated or treated with KSPi. a Bioluminescence images were acquired at 18 h after KSPi treatment. b Relative fold induction was calculated using normalized bioluminescence in the control group (data represent five mice implanted with ten tumors; error bars standard error). c At 18 h after KSPi treatment, subcutaneous tumors were removed and paraffin-embedded sections were stained with anti-phospho-histone H3 antibody. d Quantitative analysis for phospho-histone H3. Fold induction is expressed by normalization of KSPi-treated tumors versus control tumors.