Table 5.
The Unadjusted and Adjusted Association of Diagnostic and Treatment Delays of Colon Cancer on CRC-Specific and All-Cause Risk of Death by Stage
| All-Cause Death | CRC-Specific Death | |||
|---|---|---|---|---|
| Unadjusted OR (95% CI) | Adjusteda OR (95% CI) | Unadjusted OR (95% CI) | Adjustedb OR (95% CI) | |
| Diagnostic Delay | ||||
| Total | (n=6666)c | (n=6365)c | ||
| <2 weeks | 1.23 (1.06-1.42) | 1.07 (0.88-1.31) | 1.27 (1.08-1.49) | 1.13 (0.92-1.39) |
| 14-59 days | 1 | 1 | 1 | 1 |
| 2-4 months | 1.11 (0.94-1.32) | 1.11 (0.88-1.41) | 0.98 (0.81-1.20) | 1.11 (0.87-1.42) |
| 4-8 months | 1.05 (0.90-1.23) | 0.94 (0.75-1.16) | 0.76 (0.63-0.92) | 0.88 (0.70-1.11) |
| ≥8 months | 1.33 (1.17-1.52) | 1.31 (1.08-1.58) | 0.82 (0.71-0.96) | 1.04 (0.85-1.26) |
| Local Stage | (n=2841) | (n=2114) | ||
| <2 weeks | 1.21 (0.94-1.56) | 0.96 (0.71-1.31) | 1.33 (0.86-2.04) | 1.05 (0.66-1.67) |
| 14-59 days | 1 | 1 | 1 | 1 |
| 2-4 months | 1.15 (0.87-1.53) | 1.09 (0.77-1.55) | 0.99 (0.59-1.65) | 0.94 (0.54-1.62) |
| 4-8 months | 1.30 (1.01-1.69) | 1.08 (0.78-1.49) | 1.03 (0.65-1.64) | 0.93 (0.57-1.53) |
| ≥8 months | 1.65 (1.33-2.06) | 1.23 (0.93-1.63) | 1.11 (0.75-1.66) | 0.91 (0.59-1.42) |
| Regional Stage | (n=2667) | (2523) | ||
| <2 weeks | 1.18 (0.94-1.48) | 1.13 (0.84-1.51) | 1.34 (1.03-1.75) | 1.19 (0.88-1.59) |
| 14-59 days | 1 | 1 | 1 | 1 |
| 2-4 months | 1.11 (0.84-1.46) | 1.01 (0.71-1.43) | 0.92 (0.65-1.29) | 0.89 (0.61-1.28) |
| 4-8 months | 1.22 (0.96-1.55) | 0.97 (0.71-1.32) | 0.97 (0.72-1.31) | 0.93 (0.67-1.29) |
| ≥8 months | 1.47 (1.19-1.81) | 1.31 (1.00-1.72) | 0.99 (0.77-1.27) | 1.00 (0.76-1.32) |
| Distant Stage | (n=964) | (n=1011) | ||
| <2 weeks | 1.19 (0.75-1.88) | 1.17 (0.59-2.32) | 1.06 (0.70-1.60) | 0.97 (0.63-1.51) |
| 14-59 days | 1 | 1 | 1 | 1 |
| 2-4 months | 1.60 (0.87-2.94) | 2.23 (0.89-5.58) | 1.77 (0.99-3.17) | 1.99 (1.07-3.67) |
| 4-8 months | 0.76 (0.46-1.25) | 0.52 (0.24-1.16) | 0.53 (0.34-0.83) | 0.69 (0.42-1.13) |
| ≥8 months | 2.78 (1.52-5.11) | 2.37 (1.01-5.56) | 1.00 (0.66-1.52) | 1.31 (0.82-2.11) |
| Treatment Delay | ||||
| Total | (n=6669)c | (n=6238)c | ||
| <1 week | 1.55 (1.35-1.79) | 1.23 (1.01-1.49) | 1.30 (1.10-1.53) | 1.07 (0.87-1.31) |
| 1-2 weeks | 1 | 1 | 1 | 1 |
| 2-4 weeks | 0.75 (0.65-0.87) | 1.03 (0.85-1.26) | 0.66 (0.55-0.78) | 0.92 (0.74-1.14) |
| ≥4 weeks | 0.84 (0.71-1.00) | 1.00 (0.79-1.27) | 0.57 (0.46-0.70) | 0.80 (0.62-1.05) |
| Local Stage | (n=2802) | (n=2035) | ||
| <1 week | 1.74 (1.34-2.26) | 1.43 (1.04-1.96) | 1.32 (0.82-2.13) | 1.14 (0.69-1.89) |
| 1-2 weeks | 1 | 1 | 1 | 1 |
| 2-4 weeks | 0.96 (0.74-1.24) | 1.18 (0.86-1.62) | 0.78 (0.48-1.25) | 0.84 (0.51-1.38) |
| ≥4 weeks | 1.13 (0.85-1.50) | 1.15 (0.80-1.64) | 0.77 (0.45-1.32) | 0.71 (0.40-1.25) |
| Regional Stage | (n=2791) | (n=2593) | ||
| <1 week | 1.45 (1.16-1.80) | 1.24 (0.94-1.63) | 1.43 (1.10-1.86) | 1.26 (0.95-1.67) |
| 1-2 weeks | 1 | 1 | 1 | 1 |
| 2-4 weeks | 0.91 (0.72-1.13) | 1.13 (0.85-1.49) | 0.90 (0.69-1.18) | 1.04 (0.78-1.40) |
| ≥4 weeks | 1.11 (0.85-1.45) | 1.06 (0.75-1.50) | 0.76 (0.54-1.07) | 0.78 (0.54-1.14) |
| Distant Stage | (n=855) | (n=921) | ||
| <1 week | 0.72 (0.43-1.21) | 0.54 (0.26-1.13) | 0.67 (0.44-1.04) | 0.71 (0.45-1.14) |
| 1-2 weeks | 1 | 1 | 1 | 1 |
| 2-4 weeks | 0.57 (0.33-0.99) | 0.61 (0.27-1.37) | 0.78 (0.48-1.27) | 0.87 (0.52-1.47) |
| ≥4 weeks | 0.88 (0.41-1.86) | 0.73 (0.26-2.07) | 0.97 (0.51-1.83) | 1.10 (0.54-2.24) |
All-cause models adjusted for: stage, comorbidity, treatment type, preventable hospitalizations, year of diagnosis, low income, race, gender, age, marital status, tumor grade.
CRC-specific models adjusted for: stage, comorbidity, treatment type, year of diagnosis, race, gender, age, tumor grade, tumor location (in diagnostic delay model only), histology (in treatment delay model only).
Stage-specific numbers may not add up to equal the total sample, because matching was conducted separately for each model, and unmatched cases and controls were dropped.
OR=Odds ratio; CI=Confidence interval. Bold font indicates p<.05.