TABLE 1.

Parameters of cholesterol metabolism in WT and Cyp3a^−/− mice

	Genotype
Parameter	WT	Cyp3a−/−
Body weight (g)	23.7 ± 0.3	27.7 ± 1.1a
Liver weight (g)	1.0 ± 0.03	1.5 ± 0.07b
Plasma lathosterol (ng/ml)	32.1 ± 2.0	41.3 ± 7.9
Plasma total cholesterol (mg/dl)	63.4 ± 9.8	82.6 ± 7.5
Liver total cholesterol (mg/g)	2.8 ± 0.14	2.2 ± 0.03c
Liver 25-hydroxy-cholesterol (ng/g)	20.0 ± 1.4	14.9 ± 1.3c

Different groups of animals were used for measurements of plasma lathosterol, plasma cholesterol, liver cholesterol, and liver 25-hydroxy-cholesterol. Data for body and liver weight represent the mean ± SEM of nine mice in each group. Data for cholesterol and 25-hydroxy-cholesterol levels are shown as means ± SEM of three and six mice in each group, respectively. Data for lathosterol levels are expressed as a mean ± SD of three independent determinations, using pooled plasma from six mice.

^aP < 0.01 versus WT mice.

^bP < 0.001 versus WT mice.

^cP < 0.05 versus WT mice.