Fig. 3.
A: Hydrogen-bonding network between VDR and LCA derivatives, LCA, 3-keto LCA, LCA acetate, and LCA propionate. The purple fishnet is the Fo-Fc omit-annealed difference Fourier electron-density map contoured at 3σ level from the average of the map. The oxygen atoms of water are represented by red spheres. B: Superposition of the four LCA derivatives in VDR complexes. LCA, 3-keto LCA, LCA acetate, and LCA propionate are represented in red, green, cyan, and magenta, respectively. C: Superposition of LCA acetate (green) and 1,25(OH)2D3 (magenta) in VDR complexes.