. 2013 Jun 26;2013:204237. doi: 10.1155/2013/204237

Table 4.

Pharmacokinetic parameters of some lead drugs.

Drug	Available forms	Experimental organisms	Pharmacokinetic parameters						References
Drug	Available forms	Experimental organisms	Oral bioavailability (%)	C _max⁡ ^b (μg/mL)	t _max⁡ ^c (h)	Protein binding (%)	Half time (h)	Elimination	References
E1210	Oral/IV^a	Mice	57.5	0.11	0.5	High	2.2	nr^d	[80]
Albaconazole	Oral	Healthy human volunteers	nr^d	5–80 (proportional to dose)	2–4	98	30–56	Feces	[81, 82]
Isavuconazonium	Oral	Healthy human volunteers	Very high	1.03 (100 mg dose)	0.75–1	98	56–77	Feces	[81–83]
Isavuconazole	IV^a	Healthy human volunteers	nr^d	1.45 (100 mg dose)	1.3–5	98	76–104	Feces	[81–83]

^aIV: intravenous; ^b C _max⁡: maximal concentration; ^c t _max⁡: time to reach maximal plasma concentrations after oral administration; ^dnr: not reported.