Table 4.
Drug | Available forms | Experimental organisms | Pharmacokinetic parameters | References | |||||
---|---|---|---|---|---|---|---|---|---|
Oral bioavailability (%) | C max b (μg/mL) | t max c (h) | Protein binding (%) | Half time (h) | Elimination | ||||
E1210 | Oral/IVa | Mice | 57.5 | 0.11 | 0.5 | High | 2.2 | nrd | [80] |
Albaconazole | Oral | Healthy human volunteers | nrd | 5–80 (proportional to dose) |
2–4 | 98 | 30–56 | Feces | [81, 82] |
Isavuconazonium | Oral | Healthy human volunteers | Very high | 1.03 (100 mg dose) |
0.75–1 | 98 | 56–77 | Feces | [81–83] |
Isavuconazole | IVa | Healthy human volunteers | nrd | 1.45 (100 mg dose) |
1.3–5 | 98 | 76–104 | Feces | [81–83] |
aIV: intravenous; b C max: maximal concentration; c t max: time to reach maximal plasma concentrations after oral administration; dnr: not reported.