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Inhibition of p38 kinase reduces COX-2 in UV-irradiated keratinocytes. Subconfluent wild-type keratinocytes (a)–(d) or Egfr-null keratinocytes (b) were treated with AG1478 (a), PD169316 (c), (d), or vehicle alone (a), (c), (d), followed by exposure to 200 J/m2 or sham irradiation. Fifteen minutes (a)–(c) or 16 h later (d), protein lysate was prepared. Samples were immunoblotted with the indicated antibodies. Data are representative of three experiments performed with similar results.
