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. 2013 Jul 11;4:192. doi: 10.3389/fimmu.2013.00192

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Copyright © 2013 Hargadon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Summary of tumor-altered DC function. Illustrated here are the mechanisms by which tumors alter DC function and the processes by which these altered cells impact host anti-tumor immunity. Tumors secrete a variety of factors that can: (1) inhibit differentiation of DC from precursors, (2) induce differentiation of DC precursors into immunosuppressive MDSC or TAM, (3) suppress maturation, activation, and stimulatory APC function of already differentiated DC, and (4) induce development of immunosuppressive regulatory DC.