Table 3.
Induction and suppressive activity of tumor-associated regulatory DC.
| Tumor-derived factor | RegulatoryDC activity | Impact onhost immunity |
|---|---|---|
| TGFβ, PGE2 | ↓MHC II | ↓T cell proliferation |
| ↓CD40 | ↓T cell effector function | |
| ↑B7-H1 | ||
| ↑Arginase I | ||
| VEGF | ↑IL-10 | ↓T cell effector function |
| CCL2, CXCL1, CXCL5 | ||
| Glycans | ||
| COX-2/PGE2 | ||
| MUC1 mucins | ↓IL-12 | ↓T cell proliferation |
| ↑IL-10 | ↓CTL activity | |
| T cell anergy | ||
| ↑CD4+ Tregs | ||
| IL-6, IL-10, TGFβ | ↓IL-12 | ↓TH1 polarization |
| ↑IL-10 | ↓CTL activity | |
| ↓Ab response | ||
| ??? | ↑TGFβ | ↑CD4+ Tregs |
| PGE2 | ↑IDO by pDC | CD8+ T cell anergy |
| ↓IL-6 by pDC | ↑CD4+ Tregs | |
| TGFβ, TNFα | ↓IFNα by pDC | ↑CD4+ Tregs |
| ↑CD8+ Tregs | ||
| ??? | ↑ICOS-L by pDC | ↑CD4+ Tregs |
???, unidentified factor(s).