Table 1.
Percentile and clinically-relevant based cutoffs used to construct total physiologic dysfunction composite score.
| Components of Physiologic Dysfunction Score | Clinically-relevant Algorithm(38) (N above, below cutoff) | Percentile-based Algorithm | |
|---|---|---|---|
| Systolic blood pressure (SBP)(11) | > 140 mmHg | (362; 4149) | > 130 mmHg |
| Diastolic blood pressure (DBP)(11) | > 90 mmHg | (290; 4221) | > 78 mmHg |
| Waist to hip ratio (WHR)(55) | > 0.9 (men) > 0.8 (women) | (1456; 632) (1257; 1166) | > 0.98 |
| Glycohemoglobin (GH)(56) | > 6.4% | (206; 4305) | > 5.6% |
| Albumin (ALB)(57) | < 3.8 g/dL | (513; 3998) | < 3.9 g/dL |
| Creatinine clearance (CC)(58) | < 60 mL/min | (146; 4365) | < 67 mL/min |
| Total cholesterol (TC)(11) | > 240 mg/dL | (664; 3847) | > 220 mg/dL |
| Triglycerides (TG)(11) | > 200 mg/dL | (682; 3829) | > 154 mg/dL |
| White Blood Cell Count (WBC)1 | > 8.4 × 109 cells /L | (1102; 3409) | > 8.4 × 109 cells /L |
| Resting heart rate (HR)(59) | > 90 bpm | (452; 4059) | > 84 bpm |
1
Clinically-relevant cutoff could not be identified
SBP = systolic blood pressure; DBP = diastolic blood pressure; WHR = waist to hip ratio; GH = glycohemoglobin; ALB = albumin; CC = creatinine clearance; TC = total cholesterol; TG = triglycerides; WBC = white blood cell count; HR = resting heart rate