Table 3.

Fully-adjusted multiple linear regression model coefficients predicting log simple reaction time (SRTT), log symbol digit substitution test (SDST), and serial digit learning test (SDLT).¹,²,³

Physiologic Dysfunction Components and Overall Score6	Log(SRTT) Coefficient (95% CI)4,5	Log(SDST) Coefficient (95% CI)4,5	SDLT Coefficient (95% CI)5
SBP	−0.0002 (−0.0008, 0.0003)	−0.00008 (−0.0007, 0.0005)	0 (−0.01, 0.011)
DBP	0.00006 (−0.0007, 0.0008)	0.0003 (−0.0004, 0.001)	0.007 (−0.008, 0.022)
WHR	0.000002 (−0.00001, 0.00001)	−0.000002 (−0.00001, 0.00001)	0.00005 (−0.0001, 0.0002)
GH	0.007 (−0.001, 0.015)	0.01 (−0.002, 0.03)	0.08 (−0.146, 0.307)
ALB	−0.045 (−0.071, −0.018)	−0.018 (−0.04, 0.003)	−0.236 (−0.896, 0.425)
CC	0.0003 (−0.00002, 0.0007)	0.00002 (−0.0003, 0.0004)	0.006 (−0.001, 0.013)
TC	−0.0001 (−0.0003, 0.00004)	−0.0001 (−0.0003, 0.0001)	0.002 (−0.002, 0.006)
TG	0.00002 (−0.00002, 0.00007)	0.00002 (−0.00003, 0.00007)	0.002 (−0.0002, 0.004)
WBC	0.001 (−0.002, 0.004)	0.002 (−0.002, 0.005)	0.048 (−0.021, 0.116)
HR	0.00009 (−0.0006, 0.0007)	0.0002 (−0.0004, 0.0008)	0.006 (−0.01, 0.021)
Overall Score	0.002 (−0.003, 0.007)	0.007 (0, 0.013)	0.207 (0.066, 0.348)

¹Calculated with CNS sub-sample weights

²bold indicates two-sided significance of coefficients at 5% level

³Adjusted covariates include: sociodemographic model covariates + familiarity with computers, recent alcohol use, test language, energy level, self-reported history of stroke, and perceived average physical activity.

⁴Test scores are log transformed

⁵Calculated using clinical cutoffs

SRTT = simple reaction time test; SDST = symbol digit substitution test; SDLT = serial digit learning test; SBP = systolic blood pressure; DBP = diastolic blood pressure; WHR = waist to hip ratio; GH = glycohemoglobin; ALB = albumin; CC = creatinine clearance; TC = total cholesterol; TG = triglycerides; WBC = white blood cell count; HR = resting heart rate