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. Author manuscript; available in PMC: 2013 Jul 11.
Published in final edited form as: Nat Biotechnol. 2012 Jan 15;30(2):159–164. doi: 10.1038/nbt.2106

Figure 1.

Figure 1

Figure 1

Disease-associated proteins in the human structural interaction network (hSIN). (a) The procedure used to create the structural interaction network and to relate disease genes and mutations to this network. (b) Network representation of the main connected component of hSIN. Nodes represent proteins and edges correspond to structurally resolved interactions. Colored nodes indicate disease-associated proteins. The arrows point to the two main hubs: disease hub TP53 with 32 diseases and interaction hub GRB2 with 56 structurally resolved interactions. (c) Co-expression correlation of interacting proteins in the unfiltered interaction network, hPIN and hSIN. (d) Enrichment of functionally similar pairs in the unfiltered interaction network, hPIN and hSIN.