. Author manuscript; available in PMC: 2014 Jul 1.

Published in final edited form as: Arthritis Rheum. 2013 Jul;65(7):1764–1775. doi: 10.1002/art.37958

Table 1.

Hemophagocytosis is characteristic of fulminant MAS independent of a variety of pro-inflammatory cytokines

Mice with excessive hemophagocytosis/total mice in group
	PBS + IL10RB	KO/cytokine blocked PBS + IL10RB	WT: CpG + IL10RB	KO/cytokine blocked CpG + IL10RB

IFN-γKO	0/9	0/9	7/8	7/8
antiIL-12p40	0/3	0/3	3/3	3/3
antiTNFα	1/3	0/1	3/3	3/3
IFNARKO	0/2	0/3	3/3	4/4

Splenic touchpreps were prepared as described in Methods and a blinded pediatric hematopathologist (MP) designated each sample as excessive hemophagocytosis present or absent.