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. 2013 May 6;30(8):1966–1974. doi: 10.1093/molbev/mst085

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© The Author 2013. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 7. — We examined patterns of sequence conservation within 2 kb of mel TSS (N = 2,849). (A) The trend of SNPs around all mel TSS in sim (black) and sec (red). This plot shows the averages of a 100 bp sliding window. (B) Similar to (A), but with indels. (C) Plotted are the average sequence conservation (PhastCons 15 insect species) scores around TSS. Note that there is a dip in conservation corresponding with the spike in mutations between mel and sim. (D) We examined mel population data and plotted the frequency of segregating sites around TSS. This spike in sequence diversity upstream of TSS indicates that there is likely an increased mutation rate upstream of TSS.