Figure 12.

Diagram summarizing results of cell type‐specific protein levels for each protein examined. Changes observed in nuclear and cytoplasmic compartments are indicated in each cell‐type examined (neurones and astrocytes). Of particular interest, ATF6β in the only transcription we observed to increase in the nucleus of astrocytes, making it a particularly promising candidate as the ISR initiator protein responsible for our previously observed increase in astrocytic BiP levels [52]. Note, only proteins that exhibited a change in protein levels are indicated and not all proteins were examined for both subcellular compartments in both cell types (see chart 1 for reference). #: only determined for neurones because GFAP staining was not of a quality and consistency to allow for quantification of colocalization using this marker; *: indicates increase observed in total nuclear ATF4 levels, but because this staining was predominantly neuronal nuclei it was likely indicative of neuronal nuclear ATF4.