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. Author manuscript; available in PMC: 2013 Jul 11.
Published in final edited form as: Gastroenterology. 2011 Oct 14;142(1):21–24.e7. doi: 10.1053/j.gastro.2011.09.050

Fig. 2.

Fig. 2

A) Nuclear LacZ labeled PCs following tamoxifen treatment. B) Top: TdT-mediated dUTP nick-end labeling shows dying PCs (arrowheads). Below: Cytochrome C staining is punctate, consistent with mitochondrial localization in vehicle-treated (below left) and dispersed throughout the cytoplasm tamoxifen-treated PCs (below right) C) Cleaved caspase 3 western blot with tubulin loading control. D) At 2.5d following tamoxifen, PCs show chromatin condensation (arrows with black outline), consistent with early apoptosis. E) Another degenerating PC exhibits mitochondria ranging in morphology from normal (dashed arrow) to electron-dense-inclusion-containing (white solid arrow) to electron-dense and degenerating (arrowheads).