Table 2. Characteristics of GCT survivors according to treatment group and of healthy subjects.
| Treatment groups | |||||||
|---|---|---|---|---|---|---|---|
|
Parameters |
Healthy subjects N=360) |
Surgery (N=58) |
Carboplatin (N=21) |
Combination CT (N=176) |
All survivors (N=255) |
P-valuea |
P-valueb |
|
Demographics mean±s.d., median (min–max) | |||||||
| Age at diagnosis (years) |
NA |
30.4±8.3 28.9 (20.0–61.9) |
37.6±12.2 33.8 (24.8–50.6) |
31.2±8.8 29.6 (14.2–54.2) |
31.4±8.7 29.8 (14.2–61.9) |
∼ |
∼ |
| Age at blood analysis (years) |
43.1±14.6 44.0 (18–70) |
36.6±10.4 36.5 (20.1–69.5) |
42.1±12.0 39.3 (26.8–57.4) |
38.7±10.9 38.7 (18.2–63.4) |
39.2±10.7 38.3 (18.2–69.5) |
NS |
NS |
| Interval between curative treatment and blood analysis (years) |
NA |
6.2±6.7 3.2 (0.1–2) |
4.5±3.5 3.1 (0.7–13.2) |
8.8±7.8 6.3 (0.6–30.2) |
7.8±7.4 5.0 (0.1–30.2) |
∼ |
∼ |
|
Clinical characteristics: median (min–max) | |||||||
| Body weight (kg) |
85 (54–138) |
82 (60–138) |
83 (64–132) |
85 (60–126) |
84 (60–138) |
0.005 |
0.01 |
| Height (m) |
1.80 (1.57–2.06) |
1.85 (1.65–1.99) |
1.83 (1.69–1.98) |
1.83 (1.65–2.01) |
1.83 (1.65–2.01) |
0.006 |
<0.001 |
| Body mass index (kg m−2) |
25.8 (19.5–42.6) |
24.2 (16.8–38.5) |
25.0 (20.5–35.8) |
25.6 (18.4–36.4) |
25.5 (16.8–38.5) |
NS |
0.01 |
| Waist circumference (cm) |
94 (74–130) |
92 (85–134) |
96 (81–137) |
96 (67–124) |
96 (67–137) |
<0.001 |
0.003 |
| Systolic blood pressure (mm Hg)c |
130 (110–200) |
122 (95–185) |
130 (90–155) |
126 (90–200) |
125 (90–200) |
NS |
0.006 |
| Diastolic blood pressure (mm Hg)c |
80 (62–110) |
80 (54–110) |
80 (65–90) |
80 (53–114) |
80 (53–114) |
NS |
NS |
| Creatinine clearance (Cockroft formula; ml min−1) | 122 (84–205) | 120 (70–165) | 123 (56–217) | 122 (56–217) | ∼ | ∼ | |
Abbreviations: CT=chemotherapy; GCT=germ cell tumour; NA=not applicable; NS=not significant.
a
P-value for comparison between values of combination-CT survivors and healthy subjects (independent-samples Student's t-test or independent-samples Mann–Whitney where appropriate).
b
P-value for comparison between values of all survivors and healthy subjects (independent-samples Student's t-test or independent-samples Mann–Whitney where appropriate).
c
Systolic and diastolic blood pressure measurements for survivors treated with anti-hypertensive medication are excluded.