Table 3. Serum concentration of lipids, glucose and gonadal hormones in GCT survivors according to treatment group and in healthy subjects.
| Treatment groups | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
Parameters: median (min–max) |
Healthy subjects (N=360) |
Surgery (N=58) |
Carboplatin (N=21) |
Combination CT (N=176) |
All survivors (N=255) |
P-valuea |
P-valueb |
P-valuec |
Normal reference range |
|
Glucose and fat metabolism | |||||||||
| S. glucosed | 5.1 (3.4–7.1) | 4.8 (3.6–6.5) | 5.0 (4.1–6.2) | 5.1 (3.0–9.7) | 5.0 (3.0–9.7) | NS | NS | NS | 3.1–6.4 mmol l−1 |
| S. cholesterole | 4.90 (2.50–8.10) | 4.42 (2.88–7.11) | 5.30 (3.75–7.40) | 5.20 (2.42–9.25) | 5.07 (2.42–9.25) | 0.006 | 0.001 | 0.01 | 3.90–7.30 mmol l−1 |
| S. HDL-cholesterole | 1.34 (0.64–2.90) | 1.33 (0.68–2.70) | 1.43 (0.94–1.70) | 1.36 (0.60–4.07) | 1.35 (0.60–4.07) | NS | NS | NS | 0.70–1.50 mmol l−1 |
| S. LDL-cholesterole | 2.88 (1.26–5.66) | 3.17 (1.59–5.28) | 3.63 (1.77–5.80) | 3.46 (0.54–7.08) | 3.40 (0.54–7.08) | NS | <0.001 | <0.001 | 0.70–4.50 mmol l−1 |
| S. triglyceridee |
1.17 (0.40–4.25) |
1.00 (0.40–4.31) |
1.26 (0.67–3.42) |
1.27 (0.27–7.40) |
1.25 (0.27–7.40) |
0.01 |
0.005 |
0.05 |
0.80–2.30 mmol l−1 |
|
Gonadal hormones | |||||||||
| S. testosteronef | 16.8 (7.6–33.9) | 15.8 (11.1–25.8) | 14.1 (6.4–32.1) | 14.9 (6.4–38.2) | 0.04 | 8–35 (nmol l−1) | |||
| S. estradiol | 69 (28–151) | 67 (29–106) | 76 (10–226) | 74 (10–226) | 0.05 | 70–200 (pmol l−1) | |||
| S. LH | 5.9 (0.1–36.4) | 4.7 (2.6–25.9) | 6.8 (0.4–48.1) | 6.4 (0.1–48.1) | NS | 2.0–10.0 (U l−1) | |||
| S. FSH | 9.7 (3.6–46.7) | 10.1 (3.9–42.8) | 14.5 (0.2–98.1) | 12.4 (0.2–98.1) | <0.002 | 2.0–10.0 (U l−1) | |||
| S. SHBG |
|
28 (3–75) |
28 (16–55) |
29 (2–67) |
28 (2–75) |
NS |
|
|
20–55 (nmol l−1) |
|
Biochemical parameters | |||||||||
| S. lactate dehydrogenase | 319 (129–753) | 176 (130–494) | 319 (72–531) | 316 (72–753) | NS | 100–248 (U l−1) | |||
| S. C-reactive protein | <3 (<3–18) | <3 (<3–6) | <3 (<3–30) | <3 (<3–30) | NS | <10 (μmol l−1) | |||
Abbreviations: CT=chemotherapy; FSH=follicle-stimulating hormone; GCT=germ cell tumour; HDL=high-density lipoprotein; LDL=low-density lipoprotein; LH=luteinising hormone; NS=not significant; S.=serum; SHBG=sex hormone-binding globulin.
P-value for comparison of gonadal hormones and biochemical parameters between surgery and combination-CT survivors (independent-samples Mann–Whitney used).
P-value for comparison of glucose and fat metabolism between healthy subjects and combination-CT survivors (independent-samples Mann–Whitney used).
P-value for comparison of glucose and fat metabolism between healthy subjects and all survivors (independent-samples Mann–Whitney used).
Serum glucose and insulin measurements for survivors treated with anti-diabetic medication are excluded.
Serum cholesterol measurements for survivors treated with cholesterol-lowering medication are excluded.
34 Survivors; 1 surgery and 31 combination-CT survivors had serum testosterone levels<10.4 μmol l−1.