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. 2013 Jun 27;109(1):76–82. doi: 10.1038/bjc.2013.335

Figure 3.

Figure 3

NF-kB and IRF-1 activation. (A) Single-cell images showing different NF-κB and IRF-1 subcellular distribution. From the top to the bottom: NF-κB and IRF-1 predominantly located in the cytoplasm; NF-κB predominantly translocated to the nucleus and IRF-1 predominantly localised in the cytoplasm; NF-κB predominantly localised in the cytoplasm and IRF-1 predominantly translocated to the nucleus; and both NF-κB and IRF-1 predominantly translocated to the nucleus. (B) Population statistics of the IRF-1 and NF-κB nuclear translocation of the cell line # 2155. (C) Correlation between NF-κB and IRF-1 nuclear translocation scores in controls and (D) in IFN-γ plus TNF-α-stimulated cell lines. ρ: Spearman correlation.