Table 3. Univariate and multivariate analyses of MSKCCa and systemic inflammation markersb on overall survival.
| |
Univariate analysis |
Multivariate modelc |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Factors | n | HR | 95% | CI | P-value | HR | 95% | CI | P-value |
| Neutrophils⩾7.5 × 109/l |
41 |
2.71 |
1.91 |
3.84 |
<.0001 |
1.66 |
1.12 |
2.45 |
0.01 |
| Neutrophils<7.5 × 109/l |
321 |
1.00 |
|
|
|
1.00 |
|
|
|
| Platelets⩾400 × 109/l |
80 |
2.24 |
1.72 |
2.92 |
<.0001 |
1.48 |
1.09 |
2.00 |
0.01 |
| Platelets< 400 × 109/l |
282 |
1.00 |
|
|
|
1.00 |
|
|
|
| Albumin⩽35 mg dl−1 |
69 |
2.48 |
1.87 |
3.30 |
<.0001 |
|
|
|
|
| Albumin>35 mg dl−1 |
293 |
1.00 |
|
|
|
|
|
|
|
| Lymphocytes<1.0 × 109/l |
66 |
1.54 |
1.15 |
2.07 |
0.004 |
|
|
|
|
| Lymphocytes⩾1.0 × 109/l |
296 |
1.00 |
|
|
|
|
|
|
|
| Neutrophils/lymphocytes ratio >3 |
188 |
1.87 |
1.48 |
2.37 |
<.0001 |
1.42 |
1.10 |
1.84 |
0.008 |
| Neutrophils/lymphocytes ratio⩽3 |
174 |
1.00 |
|
|
|
1.00 |
|
|
|
| Platelets/lymphocytes ratio >195 |
178 |
1.88 |
1.48 |
2.37 |
<.0001 |
|
|
|
|
| Platelets/lymphocytes ratio⩽195 |
184 |
1.00 |
|
|
|
|
|
|
|
| KPS<80 |
59 |
2.86 |
2.13 |
3.85 |
<.0001 |
2.27 |
1.66 |
3.09 |
<.0001 |
| KPS⩾80 |
303 |
1.00 |
|
|
|
1.00 |
|
|
|
| Corrected calcium⩾10 mg dl−1 |
98 |
2.26 |
1.74 |
2.94 |
<.0001 |
1.53 |
1.15 |
2.04 |
0.003 |
| Corrected calcium<10 mg dl−1 |
264 |
1.00 |
|
|
|
1.00 |
|
|
|
| Low haemoglobind |
169 |
1.93 |
1.53 |
2.44 |
<.0001 |
1.27 |
0.97 |
1.67 |
0.09 |
| Normal haemoglobind | 193 | 1.00 | 1.00 | ||||||
Abbreviations: CI=confidence interval; HR=hazard ratio; KPS=Karnofsky Performance Status Scale; MSKCC=Memorial Sloan-Kettering Cancer Centre.
a
MSKCC factors are Karnofsky Performance Status Scale, haemoglobin, and corrected calcium.
b
Systemic inflammation markers are neutrophils, platelets, and neutrophils–lymphocytes ratio.
c
Multivariate model retained all MSKCC factors, and only systemic inflammation factors with P<0.05.
d
Haemoglobin normal>13 g dl−1 (male); >11.5 g dl−1 (female).