Table 3. Combinations of medications and risk of advanced neoplasia in those with colorectal pathology at colonoscopy.
| Aspirin | Statin | ACE-i | Aspirin and Statin | |||||
|---|---|---|---|---|---|---|---|---|
| All patients, n |
451 |
621 |
371 |
371 |
||||
| OR (95% CI) |
0.68 (0.56–0.83) |
P<0.001 |
0.65 (0.55–0.78) |
P<0.001 |
0.71 (0.57–0.89) |
P=0.002 |
|
|
|
Aspirin,
n(%) | ||||||||
| No | 250 (40) | 170 (46) | ||||||
| Yes |
|
|
371 (60) |
201 (54) |
|
|
||
| OR (95% CI) |
|
|
0.69 (0.56–0.86) |
P=0.001 |
0.67 (0.51–0.90) |
P=0.006 |
|
|
|
Statin,
n(%) | ||||||||
| No | 93 (25) | |||||||
| Yes |
|
|
|
|
278 (75) |
|
|
|
| OR (95% CI) |
|
|
|
|
0.64 (0.50–0.83) |
P<0.001 |
|
|
|
ACE-i,
n(%) | ||||||||
| No | 192 (52) | |||||||
| Yes |
|
|
|
|
|
|
179 (48) |
|
| OR (95% CI) | 0.66 (0.49–0.90) | P=0.007 | ||||||
Abbreviations: ACE-i=angiotensin-converting enzyme inhibitor; CI=confidence interval; OR=odds ratio.
Reference category=non-significant pathology.