Table 4. Risk of cancer in those with advanced neoplasia at colonoscopy.
| |
All patients |
Cancer |
Advanced adenoma |
|
Risk of cancer (multivariate analysis) |
|
|
|||
|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | P-value | OR | 95% CI | P-value | |
| |
1704 |
|
392 |
|
1312 |
|
|
|
|
|
|
Age | ||||||||||
| ⩽55 | 263 | 15 | 46 | 12 | 217 | 17 | 1 | |||
| 56–64 | 513 | 30 | 104 | 27 | 409 | 31 | 1.22 | 0.82–1.80 | 0.323 | |
|
⩾65 |
928 |
55 |
242 |
62 |
686 |
52 |
0.001 |
1.72 |
1.20–2.45 |
0.003 |
|
Sex | ||||||||||
| Male | 1201 | 70 | 260 | 66 | 941 | 72 | 1 | |||
| Female |
503 |
30 |
132 |
34 |
371 |
28 |
0.04 |
0.75 |
0.59–0.96 |
0.023 |
|
Deprivation category |
|
|
|
|
|
|
|
|
|
|
| 1 (most deprived) | 554 | 33 | 118 | 30 | 436 | 33 | ||||
| 2 | 324 | 19 | 66 | 17 | 258 | 20 | ||||
| 3 | 278 | 16 | 72 | 19 | 206 | 16 | ||||
| 4 | 232 | 14 | 63 | 16 | 169 | 13 | ||||
| 5 (least deprived) |
313 |
18 |
71 |
18 |
242 |
19 |
0.184 |
|
|
|
|
Type of positive stool test | ||||||||||
| gFOBt | 353 | 21 | 128 | 33 | 225 | 17 | 1 | |||
| FIT |
1351 |
79 |
264 |
67 |
1087 |
83 |
<0.001 |
2.41 |
1.87–3.12 |
<0.001 |
|
Aspirin |
|
|
|
|
|
|
|
|
|
|
| No | 1488 | 87 | 349 | 89 | 1139 | 87 | ||||
| Yes |
216 |
13 |
43 |
11 |
173 |
13 |
0.247 |
|
|
|
|
Statin |
|
|
|
|
|
|
|
|
|
|
| No | 1409 | 83 | 336 | 86 | 1073 | 82 | ||||
| Yes |
295 |
17 |
56 |
14 |
239 |
18 |
0.071 |
|
|
|
|
ACE-i |
|
|
|
|
|
|
|
|
|
|
| No | 1524 | 89 | 353 | 90 | 1171 | 89 | ||||
| Yes |
180 |
11 |
39 |
10 |
141 |
11 |
0.652 |
|
|
|
|
⩾1 Medications |
|
|
|
|
|
|
|
|
|
|
| No | 1330 | 78 | 318 | 81 | 1012 | 77 | ||||
| Yes | 374 | 22 | 74 | 19 | 300 | 23 | 0.094 | |||
Abbreviations: ACE-i=angiotensin-converting enzyme inhibitor; CI=confidence interval; FIT=faecal immunochemical test; gFOBt=guaiac-based faecal occult blood test; OR=odds ratio.