Table 3.
Influence of primary normal mammary fibroblasts on growth and differentiation of S1 cells in 3D-collagen I matrix.
Patient ID | Induction of growth arrest in coculture with NF at day 9 |
(%) of polarized acini in coculture with NF |
(%) of polarized acini in coculture with HMF |
(%) of polarized acini in monoculture |
---|---|---|---|---|
ANF/CAF | + | 59a | 50a | 22 |
BNF/CAF | + | 64a | 67a | 30 |
CNF/CAF | − | 26 | 54a | 24 |
DNF/CAF | − | 52a | 55a | 23 |
ENF | + | 72a | 51a | 20 |
FNF | + | 65a | 70a | 41 |
GNF | + | 44a | 44a | 16 |
HNF | + | 59a | 60a | 20 |
NF induced growth arrest of S1 cells in coculture compared to monoculture.
NF did not influence growth of S1 cells in coculture compared to monoculture. Bold, patients with corresponding CAF samples.
Significant difference compared to monoculture (p < 0.01).