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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Ann Allergy Asthma Immunol. 2013 Jul;111(1):25–31.e1. doi: 10.1016/j.anai.2013.05.010

Figure 5.

Figure 5

Schematic of proposed eosinophil regulatory activity. Epithelial cells are shown being infected by HRV in the presence of eosinophils. The eosinophil release of TGF-β along with epithelial cell endogenous TGF-β is shown to suppress the epithelial expression of IFN-β and IFN-λ, which enables increased virus replication that could lead to more severe inflammation and asthma symptoms. The dashed line between HRV and eosinophil represents a possible activation of eosinophils directly by HRV. The dashed lines between the eosinophil and epithelial cells represent possible release of unidentified mediators from epithelial cells to regulate eosinophil function and release of unidentified mediators from eosinophils to further regulate epithelial cell activity.