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. Author manuscript; available in PMC: 2013 Jul 11.
Published in final edited form as: Doc Ophthalmol. 2009 Jul 29;120(1):25–39. doi: 10.1007/s10633-009-9181-x

Figure 2.

Figure 2

50/10 OIR model at different post-natal day ages (p) mimics what occurs in human preterm infants. (1) at birth, human preterm infants have incompletely vascularized retina; (2) approximately 6% of preterm infants born less than 1000 grams in birth weight will develop severe ROP, at which time treatment with laser is recommended to reduce unwanted intravitreous neovascularization and consequences of retinal detachment; (3) most preterm infants will undergo vascularization of the avascular retina and 50% of infants with threshold severe ROP will also have regression of the intravitreous neovascularization with ongoing vascularization of the avascular retina. The goal of our lab is to promote vascularization of avascular retina and to reduce unwanted intravitreous neovascularization.