Figure 4.

(top). Lectin-stained retinal flat mount of mouse model of hyperoxia induced vaso-obliteration and angiogenesis at p17 following 5 days of 75% oxygen and 5 days of room air showing central obliteration of retinal capillaries with endothelial budding (model developed by Lois Smith).

(bottom). Lectin-stained retinal flat mount of rat 50/10 model of oxygen induced retinopathy following 7 cycles of oxygen between 50% and 10%, then 4 days of room air exposure, showing peripheral avascular retina and intravitreous neovascularization at the junction of vascular and avascular retina.