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. Author manuscript; available in PMC: 2013 Jul 11.
Published in final edited form as: Doc Ophthalmol. 2009 Jul 29;120(1):25–39. doi: 10.1007/s10633-009-9181-x

Figure 5.

Figure 5

Graph of inspired oxygen over time in the 50/10 OIR developed by John Penn and 50/10 OIR+SO models. At postnatal day 14 pups are returned to room air (50/10 OIR) or recovered in supplemental oxygen (28% oxygen, 50/10 OIR+SO) models. The models have relevance to human ROP in that the arterial oxygen of pups in these oxygen extremes mimic the transcutaneous oxygen extremes in human preterm infants that develop severe ROP. Also fluctuations in oxygen are risks for ROP. The model also develops features similar to infants with severe ROP of today.