Table III.

Stability of oxycodone, oxymorphone and noroxycodone

Matrix/storage conditions, concentration	Analyte
	Oxycodone	Oxymorphone	Noroxycodone
	(% Target/%CV)
Plasma/room temperature for 24 h (n = 3), ng/mL
0.2	101.2/1.2	97.5/1.5	99.3/3.4
200	103.0/0.5	99.5/1.5	100.0/2.0
Plasma/−20°C for 460 days (n = 5), ng/mL
0.2	99.8/2.2	91.8/6.9	93.8/6.4
200	97.5/0.5	95.0/1.6	95.0/1.6
Plasma/three freeze–thaw cycles (n = 3), ng/mL
0.2	101.0/1.0	97.7/1.9	93.7/7.5
200	103.5/2.9	97.5/2.1	100.5/3.0
Processed Plasma/−20°C for 7 days (n = 5), ng/mL
0.2	104.3/0.3	105.0/0.5	103.5/4.7
200	103.5/1.4	102.5/0.5	102.0/2.9
Processed plasma/autosampler for 4 days (n = 5), ng/mL
0.2	112.7/14.1	99.0/3.0	95.8/6.4
200	109.0/2.3	104.5/2.9	103.0/1.9
Urine/room temperature for 24 h (n = 3), ng/mL
30.0	97.7/1.7	94.7/2.5	93.3/1.1
4000	96.3/1.1	95.6/0.2	99.6/0.6
Stock solutions, stored: (n = 5)	(% fresh stock/%CV)
−20°C for 251 days	100.6/1.1	95.4/2.2	99.1/1.0
Room temperature for 18 h	100.7/4.4	103.4/12.9	98.4/2.3

Results are derived from the mean ± SD of n = 3 or 5 per concentration.