Figure 7.

Work flow diagram. For each population, single-SNP analysis was first conducted using the family-based TDT. SNPs were then mapped to genes, and genes were mapped to pathways/gene sets based on annotation databases. Pathway level associations with childhood asthma were obtained based on gene set analysis. Overlapping and population-specific top-ranked genetic risk factors across the three populations at the locus and pathway levels were studied to investigate shared or unique pathophysiological processes in the study population.