Table 6.
Over-represented pathways and GOs
| |
p values |
||
|---|---|---|---|
| EA | AA | HA | |
| GO |
|
|
|
| Cellular response to stress |
0.0006 |
1 |
1 |
| Vitamin binding |
0.0056 |
0.3392 |
1 |
| JAK STAT cascade |
0.0062 |
1 |
0.4304 |
| Vitamin transport |
0.0072 |
0.3210 |
0.2886 |
| ER nuclear signaling pathway |
0.0078 |
1 |
1 |
| Regulation of gene-specific transcription |
0.0078 |
1 |
1 |
| Positive regulation of cell proliferation |
0.4326 |
0.0006 |
0.4412 |
| Lysosomal transport |
1 |
0.0016 |
1 |
| Carbohydrate binding |
0.6714 |
0.0038 |
0.8342 |
| RNA catabolic process |
0.3710 |
0.0050 |
0.2818 |
| Vacuolar transport |
1 |
0.0052 |
1 |
| Negative regulation of catalytic activity |
0.7328 |
0.1720 |
0.0004 |
| Protein kinase binding |
1 |
0.7450 |
0.0016 |
| Kinase binding |
0.8654 |
0.5054 |
0.0040 |
| Regulation of translation |
0.8478 |
1 |
0.0050 |
| Anion transmembrane transporter activity |
1 |
0.7148 |
0.0080 |
| Negative regulation of hydrolase activity |
1 |
1 |
0.0100 |
| Pathway |
|
|
|
| BioCarta G2 pathway |
0.0008 |
1 |
1 |
| Reactome E2F transcriptional targets at G1 S |
0.0034 |
1 |
1 |
| Reactome E2F mediated regulation of DNA replication |
0.0036 |
1 |
1 |
| KEGG alanine aspartate and glutamate metabolism |
0.5218 |
0.0032 |
0.4338 |
| BioCarta longevity pathway |
0.4426 |
0.0088 |
1 |
| Reactome amine ligand binding receptors |
0.3642 |
0.1202 |
0.0006 |
| Reactome G alpha S signaling events | 0.3682 | 0.8264 | 0.0060 |
With p value <0.01 in at least one of the three populations when the top 1,000 SNPs are declared as noteworthy. EA, European-American; AA, African-American; HA, Hispanic-American populations; KEGG, Kyoto encyclopedia of genes and genomes.