Table 7.
Population genetic differentiation and population differences in genetic association with asthma
|
Allele frequencies in CAMP and CARE |
FST |
DRP > mean (DRP) and FST > mean (FST) |
||||
|---|---|---|---|---|---|---|
| Mean | Median | Range | Observed | Expected | p valuesa | |
| From parents |
|
|
|
|
|
|
| Caucasian vs. African-American |
0.0463 |
0.0263 |
(0, 0.5858) |
108,245 |
107,720 |
0.007898 |
| Caucasian vs. Hispanic |
0.0078 |
0.0036 |
(0, 0.1770) |
95,757 |
94,447 |
7.749 × 10−12 |
| African-American vs. Hispanic |
0.0387 |
0.0215 |
(0, 0.4989) |
107,740 |
107,384 |
0.07227 |
| From the affected offspring |
|
|
|
|
|
|
| Caucasian vs. African-American |
0.0487 |
0.0274 |
(0, 0.6036) |
107,987 |
107,432 |
0.004965 |
| Caucasian vs. Hispanic |
0.0114 |
0.0050 |
(0, 0.2226) |
98,522 |
97,445 |
2.39 × 10−8 |
| African-American vs. Hispanic | 0.0433 | 0.0238 | (0, 0.5429) | 107,458 | 107,225 | 0.2408 |
ap values of the chi-square test of the frequency table of DRP > mean (DRP) and FST > mean (FST). DRP, difference between the rankings of p values in the two populations.