FIGURE 6:

Codrugging sensitizes survivor cells to TRAIL but is not as effective as waiting for cells to reset. (A) Cell viability plot of control and survivor cells treated with a range of doses of the PI3K inhibitor PI-103 with or without TRAIL (50 ng/ml) for 6 h. (B) Cell viability plot of control and survivor cells treated with a range of doses of TRAIL with or without PI-103 (1 μM) for 6 h. (C) Cell viability plot of control and survivor cells treated with a range of doses of TRAIL with or without MG-132 (1 μM) for 6 h. (D) Cell viability plot of control and survivor cells treated with a range of doses of TRAIL with or without bortezomib (0.1 μM) for 6 h. (E) Cell viability plot of control and survivor cells treated with a range of doses of TRAIL with or without doxorubicin (10 μM) for 6 h.