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Control of glucokinase. Binding of glucokinase-regulatory protein (RP) reduces the activity of glucokinase (GK). Fructose-1-P relieves the inhibition by stabilizing the dissociated RP, while F-6-P furthers inhibition by stabilizing the complex. Not shown in the figure: the GK-RP complex is transported to the nucleus [27]. Dissociation leads to transport from the nucleus.
