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. Author manuscript; available in PMC: 2013 Jul 11.
Published in final edited form as: Open Endocrinol J. 2010;4:23–32. doi: 10.2174/1874216501004010023

Fig. (4). Deletion of Akt2 does not affect islet mass in Pten null islets.

Fig. (4)

We deleted Akt2 in the PtenloxP/loxP; Rip-Cre+ mice to test whether the PI3K/AKT signaling mediated β-cell regeneration. We found that deletion of Akt2 has little effect on the regenerative islet phenotype we observed in the Pten deletion models. Pm, PtenloxP/loxP; Rip-Cre+; Dm, PtenloxP/loxP; Rip-Cre+;Akt2−/−. Repre-sentative image from 10 animals.