Table 1.
The relationship between clinicopathological variables and CK19 expression in hepatocellular carcinoma
| |
Hepatocellular carcinoma, n = 42 |
|||||
|---|---|---|---|---|---|---|
|
CK19 liver a |
|
CK19 lymph node b |
|
|||
| Negative | Positive (%) | P value | Negative | Positive (%) | P value | |
|
Age (yr) |
|
|
|
|
|
|
| ≦60 |
24 |
5 (17.2) |
0.275 |
26 |
3 (10.3) |
0.497 |
| >60 |
9 |
4 (30.8) |
|
11 |
2 (15.4) |
|
|
Gender |
|
|
|
|
|
|
| Male |
26 |
8 (23.5) |
0.443 |
30 |
4 (11.8) |
0.673 |
| Female |
7 |
1 (12.5) |
|
7 |
1 (12.5) |
|
|
Hepatitis B virus |
|
|
|
|
|
|
| Positive |
24 |
4 (14.3) |
0.117 |
26 |
2 (7.1) |
0.197 |
| Negative |
9 |
5 (35.7) |
|
11 |
3 (21.4) |
|
|
Hepatitis C virus |
|
|
|
|
|
|
| Positive |
7 |
2 (22.2) |
0.633 |
8 |
1 (11.1) |
0.712 |
| Negative |
26 |
7 (21.2) |
|
29 |
4 (12.1) |
|
|
Total bilirubin(mg/dl)c |
1.348 ± 2.373 |
0.844 ± 0.335 |
0.533 |
1.303 ± 2.236 |
0.760 ± 0.270 |
0.595 |
|
Alkaline phosphotase (U/L)c |
111.4 ± 70.447 |
93.86 ± 30.905 |
0.527 |
111.63 ± 68.54 |
85.40 ± 26.444 |
0.408 |
|
Preoperative α-fetoprotein (ng/ml)c |
8300 ± 39207 |
669.42 ± 1258 |
0.589 |
7594 ± 37510 |
1033 ± 1525 |
0.701 |
|
Child-Pugh classification |
|
|
|
|
|
|
| A |
32 |
9 (21.9) |
0.786 |
36 |
5 (12.2) |
0.881 |
| B |
1 |
0 (0) |
|
1 |
0 (0) |
|
|
Size (cm) |
9.027 ± 5.2192 |
6.156 ± 3.0121 |
0.124 |
8.519 ± 5.1876 |
7.620 ± 2.7472 |
0.708 |
|
T stage |
|
|
|
|
|
|
| T1/T2 |
13 |
5 (27.8) |
0.524 |
16 |
2 (11.1) |
0.688 |
| T3/T4 |
20 |
4 (16.7) |
|
21 |
3 (12.5) |
|
|
N stage |
|
|
|
|
|
|
| N0 |
24 |
2 (7.7) |
0.005 |
26 |
0 (0) |
0.002 |
| N1 |
9 |
7 (43.8) |
|
11 |
5 (31.3) |
|
|
Encapsulation |
|
|
|
|
|
|
| Yes |
19 |
1 (5) |
0.013 |
19 |
1 (5) |
0.203 |
| No |
14 |
8 (36.4) |
|
18 |
4 (18.2) |
|
|
Tumor rupture |
|
|
|
|
|
|
| Yes |
4 |
0 (0) |
0.366 |
4 |
0 (0) |
0.590 |
| No |
29 |
9 (23.4) |
|
33 |
5 (13.2) |
|
|
Vascular invasion |
|
|
|
|
|
|
| Yes |
12 |
4 (25) |
0.471 |
12 |
4 (25) |
0.061 |
| No |
21 |
5 (19.2) |
|
25 |
1 (3.8) |
|
|
Daughter nodules |
|
|
|
|
|
|
| Yes |
13 |
3 (18.75) |
0.529 |
15 |
1 (6.25) |
0.359 |
| No |
20 |
6 (23.07) |
|
22 |
4 (15.4) |
|
|
Resection margin |
|
|
|
|
|
|
| Positive |
4 |
1 (20) |
0.606 |
5 |
0 (0) |
0.284 |
| Negative |
29 |
8 (21.6) |
|
32 |
5 (13.5) |
|
|
Edmonson and Steiner grade |
|
|
|
|
|
|
| I/II |
15 |
4 (21.1) |
0.180 |
18 |
1 (5.3) |
0.341 |
| III/IV | 18 | 5 (21.7) | 19 | 4 (17.4) | ||
aImmunohistochemical staining of primary liver tumor specimen for CK19.
bImmunohistochemical staining of lymph nodes specimen for CK19.
cData are presented as mean±standard deviation.