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. 2013 Jul 11;7(7):e2298. doi: 10.1371/journal.pntd.0002298

Table 3. Common and differential GO pathways in early acute and late acute phases.

Phase Up-regulated GO pathways Down-regulated GO pathways
Early Acute type I interferon-mediated signaling pathway translational elongation
cytokine-mediated signaling pathway translation
immune response structural constituent of ribosome
interferon-gamma-mediated signaling pathway viral transcription
innate immune response translational termination
double-stranded RNA binding cellular protein metabolic process
response to virus viral infectious cycle
chemotaxis gene expression
inflammatory response endocrine pancreas development
defense response to virus ribosome
Late Acute mitotic cell cycle positive regulation of nitric oxide biosynthetic process
cell division positive regulation of fever generation
mitosis peroxidase activity
spindle organization haptoglobin-hemoglobin complex
cell cycle sequestering of triglyceride
DNA replication positive regulation of calcidiol 1-monooxygenase activity
M phase of mitotic cell cycle humoral immune response
phosphatidylinositol-mediated signaling oxygen transport
chromosome regulation of I-kappaB kinase/NF-kappaB cascade
cell cycle checkpoint
Both phases cytokine-mediated signaling pathway
type I interferon-mediated signaling pathway
response to virus