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. 2013 Jul 11;7(7):e2282. doi: 10.1371/journal.pntd.0002282

Table 1. Loci that control skin lesion development.

Phenotype Locus Marker Genotype P value corr. P value Bonfer. corr. P value % of explained variance
CC CS SS
lesion wk 19 Ltr2 D2Nds3 0.00 0.002±0.001 (n = 60) 0.35 0.004±0.001 (n = 127) 1.65 0.010±0.001 (n = 53) 6.6×10−5 0.004 0.049 20.90
lesion wk 19 Ltr4 D4Mit153 1.31 0.008±0.001 (n = 54) 0.23 0.003±0.001 (n = 130) 0.38 0.004±0.001 (n = 56) 0.0018 0.077 0.93 9.66
lesion wk 21 Ltr2 D2Nds3 0.20 0.003±0.002 (n = 60) 0.36 0.004±0.001 (n = 127) 2.27 0.012±0.002 (n = 53) 2.9×10−5 0.002 0.024 10.93
lesion wk 21 Ltr3 D3Mit11 0.39 0.004±0.002 (n = 64) 0.42 0.004±0.001 (n = 122) 1.94 0.011±0.002 (n = 54) 0.00088 0.042 0.50 12.48
lesion wk 23 Ltr3 D3Mit11 0.25 0.149±0.010 (n = 64) 0.28 0.152±0.008 (n = 122) 1.29 0.203±0.012 (n = 54) 0.00053 0.026 0.32 6.59
lesion wk 25 Ltr3 D3Mit11 0.52 0.069±0.008 (n = 64) 0.48 0.067±0.007 (n = 122) 2.21 0.110±0.009 (n = 54) 0.00048 0.024 0.29 12.02
lesion wk 27 Ltr4 D4Mit153 1.75 0.101±0.008 (n = 54) 0.59 0.071±0.006 (n = 130) 0.30 0.060±0.008 (n = 55) 0.00096 0.045 0.54 7.53
lesion wk 31 Ltr2 D2Mit389 1.32 0.092±0.012 (n = 55) 1.57 0.097±0.007 (n = 134) 5.53 0.148±0.011 (n = 48) 0.00028 0.015 0.18 10.77

Lesions were measured every second week. In order to normalize distribution of the observed values, the natural logarithm of the lesion size (mm2) at each measured week (value+1.5) raised to the power of 0.04 was further raised to the power of 1.5 for weeks 19, 21, 23, 25; and to the power of 0.75 for week 31. The table shows means and SE calculated by analysis of variance. Non-transformed values of mean are given in bold. Number of tested mice is shown in brackets. Only P values significant after correction for genome-wide analysis and Bonferroni correction (multiplied by the number of tested weeks) are given. C and S indicate the presence of BALB/c and STS allele, respectively.