Table 1. Loci that control skin lesion development.
Phenotype | Locus | Marker | Genotype | P value | corr. P value | Bonfer. corr. P value | % of explained variance | ||||||||
CC | CS | SS | |||||||||||||
lesion wk 19 | Ltr2 | D2Nds3 | 0.00 | 0.002±0.001 | (n = 60) | 0.35 | 0.004±0.001 | (n = 127) | 1.65 | 0.010±0.001 | (n = 53) | 6.6×10−5 | 0.004 | 0.049 | 20.90 |
lesion wk 19 | Ltr4 | D4Mit153 | 1.31 | 0.008±0.001 | (n = 54) | 0.23 | 0.003±0.001 | (n = 130) | 0.38 | 0.004±0.001 | (n = 56) | 0.0018 | 0.077 | 0.93 | 9.66 |
lesion wk 21 | Ltr2 | D2Nds3 | 0.20 | 0.003±0.002 | (n = 60) | 0.36 | 0.004±0.001 | (n = 127) | 2.27 | 0.012±0.002 | (n = 53) | 2.9×10−5 | 0.002 | 0.024 | 10.93 |
lesion wk 21 | Ltr3 | D3Mit11 | 0.39 | 0.004±0.002 | (n = 64) | 0.42 | 0.004±0.001 | (n = 122) | 1.94 | 0.011±0.002 | (n = 54) | 0.00088 | 0.042 | 0.50 | 12.48 |
lesion wk 23 | Ltr3 | D3Mit11 | 0.25 | 0.149±0.010 | (n = 64) | 0.28 | 0.152±0.008 | (n = 122) | 1.29 | 0.203±0.012 | (n = 54) | 0.00053 | 0.026 | 0.32 | 6.59 |
lesion wk 25 | Ltr3 | D3Mit11 | 0.52 | 0.069±0.008 | (n = 64) | 0.48 | 0.067±0.007 | (n = 122) | 2.21 | 0.110±0.009 | (n = 54) | 0.00048 | 0.024 | 0.29 | 12.02 |
lesion wk 27 | Ltr4 | D4Mit153 | 1.75 | 0.101±0.008 | (n = 54) | 0.59 | 0.071±0.006 | (n = 130) | 0.30 | 0.060±0.008 | (n = 55) | 0.00096 | 0.045 | 0.54 | 7.53 |
lesion wk 31 | Ltr2 | D2Mit389 | 1.32 | 0.092±0.012 | (n = 55) | 1.57 | 0.097±0.007 | (n = 134) | 5.53 | 0.148±0.011 | (n = 48) | 0.00028 | 0.015 | 0.18 | 10.77 |
Lesions were measured every second week. In order to normalize distribution of the observed values, the natural logarithm of the lesion size (mm2) at each measured week (value+1.5) raised to the power of 0.04 was further raised to the power of 1.5 for weeks 19, 21, 23, 25; and to the power of 0.75 for week 31. The table shows means and SE calculated by analysis of variance. Non-transformed values of mean are given in bold. Number of tested mice is shown in brackets. Only P values significant after correction for genome-wide analysis and Bonferroni correction (multiplied by the number of tested weeks) are given. C and S indicate the presence of BALB/c and STS allele, respectively.