Table 4. Interaction between loci controlling parasite burden in lymph nodes and liver 43 weeks after infection.
Interaction between loci that control parasite burden in liver | ||||||||
P = 0.00059 | Corrected P = 0.021 | % of explained variance = 8.11 | ||||||
D18Mit40 (Ltr8) | ||||||||
CC | CS | SS | ||||||
D4Mit153 | CC | 0.85 | 4.44±0.2 | 1.19 | 4.78±0.2 | 0.51 | 3.93±0.21 | |
( Ltr4 ) | (n = 14) | (n = 25) | (n = 14) | |||||
CS | 1.00 | 4.61±0.14 | 0.65 | 4.17±0.09 | 1.05 | 4.65±0.18 | ||
(n = 33) | (n = 72) | (n = 19) | ||||||
SS | 0.67 | 4.21±0.2 | 0.73 | 4.28±0.18 | 0.85 | 4.44±0.20 | ||
(n = 13) | (n = 22) | (n = 20) |
Means, SE and P values for concentration of parasite DNA (ng/µl) in isolates from lymph nodes and liver were computed by analysis of variance. The following transformations were used to obtain normal distribution: natural logarithm of (value×100). Hepatomegaly (liver-to-body weight ratio×1000) was normalized by raising values to the power of 0.0125. The numbers in bold give the average non-transformed values. Only P values significant after correction for genome-wide significance are given. Number of tested mice is shown in brackets. C and S indicate the presence of BALB/c and STS allele, respectively.