Table 5. Main effect of loci controlling serum chemokine level after 7 weeks of infection.
| Phenotype | Locus | Marker | Genotype | P value | corr. P value | % of explained variance | ||||||||
| CC | CS | SS | ||||||||||||
| CCL3 | Ltr3 | D3Mit11 | 711.42 | 3.72±0.18 | (n = 64) | 371.57 | 3.27±0.12 | (n = 118) | 94.68 | 2.49±0.21 | (n = 53) | 7.5×10−5 | 0.0046 | 4.56 |
| CCL5 | Ltr3 | D3Mit11 | 2724.44 | 5.15±0.08 | (n = 64) | 1805.94 | 4.98±0.05 | (n = 117) | 861.34 | 4.66±0.09 | (n = 53) | 0.00018 | 0.010 | 3.99 |
| CCL7 | Ltr2 | D2M52 | 566.41 | 6.34±0.05 | (n = 48) | 590.60 | 6.38±0.03 | (n = 127) | 740.99 | 6.61±0.05 | (n = 60) | 3×10−5 | 0.002 | 9.06 |
| CCL7 | Ltr8 | D18M40 | 766.86 | 6.64±0.05 | (n = 60) | 602.67 | 6.40±0.04 | (n = 118) | 613.11 | 6.42±0.06 | (n = 55) | 0.00024 | 0.013 | 11.38 |
In order to normalize distribution of the observed values (in pg/ml), the following transformations were used: the power of 0.2 (concentration value+1) – CCL3/MIP1α; natural logarithm – CCL7/MCP-3; the power of −0.117545 followed by subtraction with 1 – CCL5/RANTES. In case of CCL5/RANTES, the calculated value was further divided by −0.117545. The Table gives mean of non-transformed (in bold) and transformed concentration and SE of the transformed values calculated by analysis of variance. Only P values significant after correction for genome-wide significance are given. Number of tested mice is shown in brackets. C and S indicate the presence of BALB/c and STS allele, respectively.