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. 2013 Jul 11;9(7):e1003130. doi: 10.1371/journal.pcbi.1003130

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© 2013 Cron et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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, , and . To evaluate the robustness of the algorithm to changes in the configurable hyper-parameters, we repeated the analysis of the spiked in data sample multiple times with different parameters, using 10 independent MCMC runs to obtain statistics for each set of hyper-parameter configurations. Each mini-panel has the same axes as Figure 7 with estimated frequency of multimer-positive events on the vertical axis and spiked-in frequency on the horizontal axis. A boxplot is used to display the results for each model configuration. Configurable parameters were set to be either the default value (1.0), 3-fold lower (0.3) or 3-fold higher (3.0), giving 81 hyper-parameter configurations. Three replicate runs with 10,000 burn-in and 1,000 MCMC iterations were performed for each configuration. The default configuration is in the center panel with red text.

Inline graphic — , , and . To evaluate the robustness of the algorithm to changes in the configurable hyper-parameters, we repeated the analysis of the spiked in data sample multiple times with different parameters, using 10 independent MCMC runs to obtain statistics for each set of hyper-parameter configurations. Each mini-panel has the same axes as Figure 7 with estimated frequency of multimer-positive events on the vertical axis and spiked-in frequency on the horizontal axis. A boxplot is used to display the results for each model configuration. Configurable parameters were set to be either the default value (1.0), 3-fold lower (0.3) or 3-fold higher (3.0), giving 81 hyper-parameter configurations. Three replicate runs with 10,000 burn-in and 1,000 MCMC iterations were performed for each configuration. The default configuration is in the center panel with red text.