Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Jul 11;9(7):e1003119. doi: 10.1371/journal.pcbi.1003119

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 Wang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A) The number of side effects and (B) the number of human targets are displayed for different groups of drugs. The Wilcoxon rank-sum tests were used to assess the differences in distributions of side effects and human targets among different drug groups. The number of drug side effects is positively correlated with (C) the number of total targets and (D) the number of essential targets (triangles). However, the analysis on drugs with no essential targets shows no correlation between drug side effects and targets (circles). The results in panels (C) and (D) are obtained from generalized linear regressions based on negative binomial distribution for side effects. In panels (C) and (D), gray symbols are raw data while the colored ones correspond to median counts of side effects. Schematics under the x-axes illustrate a drug (hexagon) binding to its target protein(s) (filled circles).