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. 2013 Jul 11;9(7):e1003098. doi: 10.1371/journal.pcbi.1003098

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© 2013 Noor et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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in iAF1260 (E. coli) and Recon 1 (human), that were in the range of , and were thus evaluated with reactant contribution (RC). For a reaction , this fraction was calculated as . Passive and facilitated diffusion reactions, where the reactants undergo no chemical changes, are not included in the figure. 9.4% of all evaluated reactions in iAF1260 were fully evaluated using only reactant contributions. These reactions carried approximately half of the total flux (red) in 312 predicted flux distributions. The 8.3% of evaluated reactions in Recon 1 that were fully evaluated with reactant contributions, carried close to a third of the total flux in 97 predicted flux distributions.

Inline graphic — in iAF1260 (E. coli) and Recon 1 (human), that were in the range of , and were thus evaluated with reactant contribution (RC). For a reaction , this fraction was calculated as . Passive and facilitated diffusion reactions, where the reactants undergo no chemical changes, are not included in the figure. 9.4% of all evaluated reactions in iAF1260 were fully evaluated using only reactant contributions. These reactions carried approximately half of the total flux (red) in 312 predicted flux distributions. The 8.3% of evaluated reactions in Recon 1 that were fully evaluated with reactant contributions, carried close to a third of the total flux in 97 predicted flux distributions.