Figure 2. Adherence of leukocytes to the endothelia of the retinal vascular wall (leukostasis) is increased in diabetes, and occurs via MyD88-dependent signalling pathways.

Wildtype leukocytes from diabetic mice attached to the vessel wall in significantly greater numbers than did leukocytes from nondiabetic wildtypes, whereas leukocytes lacking either MyD88, TLR2/4 or IL-1βr underwent less diabetes-induced leukostasis than wildtype diabetic controls. Photomicrograph is a representative picture of a diabetic wildtyype animal. n=5 per group; representative of two repeat experiments.