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. 2013 Jul 11;8(7):e68871. doi: 10.1371/journal.pone.0068871

Figure 3. MyD88 pathways in leukocytes influence expression of ICAM-1 on retinal vascular endothelium.

Figure 3

ICAM-1 expression is estimated based on the extent of binding of anti-ICAM-1-conjugated microspheres to the retinal vasculature of diabetic and nondiabetic mice. Diabetes in wildtype chimeras caused a significant increase in the number of microspheres binding to the vessels compared to that in nondiabetic wildtype chimeras. ICAM-1 expression in retinal vessels was significantly inhibited in diabetic chimeras lacking either MyD88, TLR2/4, or IL-1βr in their leukocytes. n= 4 per group; representative of two repeat experiments.