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. 2013 Jul 11;8(7):e68293. doi: 10.1371/journal.pone.0068293

Figure 4. Sensitivity of sorted 769P SP and NSP cells to radiation and chemotherapeutic drugs.

Figure 4

A, the clone formation efficiency of sorted 769P SP cells is significantly higher than that of NSP cells either before or after 5 Gy of X-ray irradiation. The clone formation efficiency of SP cells is significantly higher than that of NSP cells after irradiation (P<0.01); the clone formation efficiency of unirradiated NSP cells is significantly higher than that of irradiated NSP cells (P<0.05). B, newly sorted 769P SP cells are more resistant to mitoxantrone than NSP cells (P<0.01), whereas this resistance is reversed with verapamil pretreatment. C, SP cells are also more resistant to 5-fluorouracil than NSP cells (P<0.05). The resistance could also be reversed with verapamil pretreatment. D, the sensitivity of SP cells to sunitinib is similar to that of NSP cells (P>0.05).