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. 2013 Jul 11;8(7):e68293. doi: 10.1371/journal.pone.0068293

Figure 7. Tumor formation ability of second-generation SP cells in NOD/SCID mice and pathological examination with H&E staining.

Figure 7

A, NOD/SCID mice were inoculated with 5,000 second-generation SP cells from a tumor formed with 2,000 SP cells or with 5,000 second-generation NSP cells from a tumor formed with 200,000 NSP cells. Tumors were removed from the mice 6 weeks after inoculation. B, the second-generation SP tumors are significantly heavier than second-generation NSP tumors (** P<0.01). C, Pathological examination shows that both the second-generation SP tumor and the second-generation NSP tumor are histologically identical to primary xenograft tumors.