Table 1. Comparative analysis of gene expression levels in HepG2 cells, primary hepatocytes, liver and HLC derived from WK1, WK6 and H9 cells.
H9 HLC | WK1 HLC | WK6 HLC | HepG2 | 1° Hep. | Liver | |
CYP2E1 | 0.01107 | 0.00624 | 0.00876 | 0.17451 | 1 | 6397.53234 |
HNF4 | 0.0005 | 0.00034 | 0.00099 | 0.32113 | 1 | 2.02913 |
HMGCR | 0.1625 | 0.1666 | 0.15494 | 0.15229 | 1 | 0.04894 |
ALB | 0.00003 | 0.00001 | 0.00001 | 0.00636 | 1 | 0.35223 |
AFP | 9153.05421 | 1139.33113 | 2809.72436 | 7585557.856 | 1 | 3.22954 |
APOA1 | 0.16837 | 0.08647 | 0.0838 | 0.05677 | 1 | 12.63807 |
APOA2 | 0.00043 | 0.00016 | 0.00023 | 0.00092 | 1 | 0.12791 |
APOA4 | 19.39736 | 2.79202 | 4.72439 | 1.06649 | 1 | 13.51947 |
APOB | 0.00024 | 0.00002 | 0.00006 | 0.02875 | 1 | 0.10088 |
APOC3 | 0.0145 | 0.00515 | 0.00516 | 0.20603 | 1 | 53.53278 |
APOE | 0.01166 | 0.00397 | 0.00657 | 0.04428 | 1 | 0.47982 |
Values for mRNA levels were expressed as fold β-actin mRNA amounts and then normalized to levels in primary hepatocytes.