Appendix Table IV.

Submitting samples and genetic counseling

	Who can submit a sample?	Is genetic counseling required?
Ambry	Requires “Clinician (geneticist/genetic counselor)” signature	“Post-test counseling and interpretation: I understand the importance of seeking genetic counseling post-testing due to the nuances. It is HIGHLY recommended that you seek genetic counseling to specifically address the risks related to any findings from this test.”
ARUP	Requires “Ordering health care provider” signature	“Genetic counseling is recommended prior to, as well as following, this complex testing.”
Baylor	Requires “Physician/Counselor” signature	“Due to the complex nature of the WES testing it is recommended that families seek genetic counseling in conjunction with testing.”
Emory	Requires “Physician/Counselor/Clinician” signature	“Given the complexity of the EmExome, genetic counseling by a trained medical geneticist or genetic counselor is required prior to and after undergoing this testing.”
GeneDx	Requires “Physician/Counselor” signature	“Because of the complexity of the test, and the type of information that might result from the test, it is important that you have genetic counseling both before and after the test is done.”
UCLA	Requires “Physician/Genetic Counselor” signature	“We recommend counseling with a clinical geneticist or genetic counselor.”

Source:

Ambry Exome Patient Consent Form (F0912-02-011p-PTM-06)

ARUP Informed Consent for Exome Sequencing with Symptom-Guided Analysis (ARUP Rev.1 5/12)

Baylor Whole Exome Sequencing Requisition - Information and Consent for Testing (Last Updated: 9/24/2012)

Emory EmExome Informed Consent Document (Rev. 6/2012)

GeneDxXomeDx Informed Consent Document (GeneDx 07/12)

UCLA Informed Consent for Postnatal Clinical Exome Sequencing