Table 4.
Screening for mutations in individuals not previously tested.
Subject | Phenotype | Gene | Genbank mRNA and CCDS ID | Mutation (cDNA) | Mutation (protein) | Zygosity of mutation |
---|---|---|---|---|---|---|
7 | OI type IV | COL1A2 | NM_000089.3, CCDS34682 | c.3938T>C | p.Leu1313Pro | Heterozygous |
8 | OI type III | COL1A1 | NM_000088.3, CCDS11561 | c.3118G>A | p.Gly1040Ser | Heterozygous |
9 | OI | COL1A1 | NM_000088.3, CCDS11561 | c.3505G>A | p.Gly1169Ser | Heterozygous |
10 | Osteopetrosis | CLCN7 | NM_001287.5, CCDS32361 | c.856C>T | p.Arg286Trp | Heterozygous |
11 | Dysosteosclerosis | No pathogenic mutation identified. This patient also had Sanger sequencing for SLC29A3 [21]. |